49ers Reveal Full 2025 NFL Schedule: Dates, Opponents & Key Games

After a disappointing 2024 season plagued by injuries and inconsistency, the San Francisco 49ers are aiming for redemption . With the NFL’s officially easiest schedule based on last year’s records , the 49ers have a prime opportunity to bounce back into playoff contention in 2025. The Niners will play all 17 games domestically and have five primetime matchups , highlighting their status as one of the league’s most-watched teams. 49ers open their season with a divisional showdown -------------------------------------------------- San Francisco kicks off the season with a tough Week 1 game on the road against the Seattle Seahawks . That sets the tone for early division matchups that will test whether this squad can recapture its 2023 playoff form. Which teams will the 49ers face? -------------------------------- The Niners will take on opponents from the NFC West, NFC South, and AFC South, along with a few intra-conference games based on last year’s standings . Home games at Levi’s Stadium include high-interest matchups against the Rams, Bears, and Seahawks. Notably, the 49ers avoid international travel this season — a possible advantage as they aim to stay fresh and focused throughout the year. Full 2025 NFL schedule for the 49ers, week by week -------------------------------------------------- * Week 1: at Seahawks * Week 2: at Saints * Week 3: vs. Cardinals * Week 4: vs. Jaguars * Week 5: at Rams (TNF) * Week 6: at Buccaneers * Week 7: vs. Falcons (SNF) * Week 8: at Texans * Week 9: at Giants * Week 10: vs. Rams * Week 11: at Cardinals * Week 12: vs. Panthers (MNF) * Week 13: at Browns * Week 14: BYE * Week 15: vs. Titans * Week 16: at Colts (MNF) * Week 17: vs. Bears (SNF) * Week 18: vs. Seahawks The bolded matchups mark the most anticipated games on the 49ers’ 2025 NFL schedule , as these bolded dates highlight key clashes that could define San Francisco’s season . Breakdown of the 49ers’ 2025 NFL matchups, home and away -------------------------------------------------------- San Francisco’s 2025 opponents posted a league-low .415 winning percentage last year . While that suggests a manageable path to double-digit wins, past trends show strength-of-schedule projections don’t always translate to success. Health and cohesion will still be critical . How to get 49ers tickets in 2025 -------------------------------- Fans can buy official tickets for all home and away games at the official 49ers website. Primetime and late-season games like the home closer vs. Seattle are expected to be in high demand . As the 49ers aim to bounce back in 2025, their favorable schedule offers a real chance to reclaim their spot among the NFL’s elite . Source: https://secretsanfrancisco.com/49ers-full-2025-nfl-schedule/