The first certain testimony of a political body governing the shores of the lake is from 818. Occupying an area of strategic importance, the lake was then part of the feudal dominion of the County of Sperio. Circa 1000, it came under the control of the Bishop of Como. The region was the site of the war between Como and Milan over control of Alpine traffic from 1218 to 1227. As the lake and its shores became progressively incorporated into the Duchy of Milan they became the subject of political and territorial contention during the 15th century, and Lugano became the lake's main town.[1]

The lake definitively ceased to belong to a single sovereign political entity following the establishment of the transalpine bailiwicks of the Swiss cantons at the beginning of the 16th century. The Italian-Swiss border was fixed in 1752 by the Treaty of Varese, and has since remained virtually unchanged.[1]

In 1848, the Melide causeway was built on a moraine between Melide and Bissone, in order to carry a road across the lake and provide a direct connection between Lugano and Chiasso. Today the causeway also carries the Gotthard railway and the A2 motorway.