The Mayor of Los Angeles has an office in room 300. Every Tuesday, Wednesday, and Friday at 10:00 am, the Los Angeles City Council meets in its chamber. An observation level is open to the public on the 27th floor. This floor's interior comprises a single large and highly vaulted room distinguished by the iconic tall square columns that are far more familiar as one of the building's most distinguishing exterior features. As this ample interior space is named, the Mayor Tom Bradley Room is used for ceremonies and other special occasions. City Hall and the adjacent federal, state, and county buildings are served by the Civic Center station on the Metro B and D subway lines and the Historic Broadway station on the Metro A and E light rail lines. The J Line stops in front of the building.

The Los Angeles Dodgers wore a commemorative uniform patch during the 2018 season celebrating 60 years in the city depicting a logo of Los Angeles City Hall.

City Hall South at 111 E. First Street, on the north side of First Street between Los Angeles and Main streets, built in 1952-4, architects Lunden, Hayward & O'Connor, International Style, originally opened as the City Health Building, housing health offices, clinics, and labs, and a central utility plant that heated City Hall proper and Parker Center (then police headquarters).